Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00127465" target="_blank" >RIV/00216224:14310/22:00127465 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00078558
Result on the web
<a href="https://www.mdpi.com/1660-4601/19/21/13898" target="_blank" >https://www.mdpi.com/1660-4601/19/21/13898</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijerph192113898" target="_blank" >10.3390/ijerph192113898</a>
Alternative languages
Result language
angličtina
Original language name
Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study
Original language description
Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25-89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant (p < 0.05) associations between the ln-transformed PFOA and glucose (beta = 0.01), systolic (beta = 0.76) and diastolic blood pressure (beta = 0.65); total cholesterol (beta = 0.07) and LDL-c (beta = 0.04); and PFOS with glucose (beta = 0.03), BMI (beta = 2.26), waist circumference (beta = 7.89), systolic blood pressure (beta = 1.18), total cholesterol (beta = 0.13), and HDL-c (beta = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Environmental Research and Public Health
ISSN
1660-4601
e-ISSN
1660-4601
Volume of the periodical
19
Issue of the periodical within the volume
21
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000881134300001
EID of the result in the Scopus database
2-s2.0-85141629095