Retention prediction of monoamine neurotransmitters in gradient liquid chromatography

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00129212" target="_blank" >RIV/00216224:14310/22:00129212 - isvavai.cz</a>

Result on the web

<a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.202200201" target="_blank" >https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.202200201</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.202200201" target="_blank" >10.1002/jssc.202200201</a>

Result language

angličtina

Original language name

Retention prediction of monoamine neurotransmitters in gradient liquid chromatography

Original language description

Retention prediction of monoamine neurotransmitters has been compared for the generally applied linear solvent-strength model and quadratic polynomial three-parameter model. The design of experiments protocol has been applied to plan linear gradients within the experimental space with altered gradient time, mobile phase flow rate, and column temperature. Relative prediction errors increased at elevated temperature, which is more significant for the linear solvent-strength model when compared to the polynomial model. On the other hand, the predefined design of experiments space controls the retention time errors, as predictions for LC conditions that are outside of the plan are much less accurate and should be avoided. The final part of the work deals with the effect of extracolumn band dispersion on the peak capacity of linear gradients at various gradient times, mobile phase flow rates, and column temperature. The peak capacity determined for corrected experimental data were consistent with the published results dealing with the optimization of peak capacity in gradient elution.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/GA20-21903S" target="_blank" >GA20-21903S: Segmented two-dimensional liquid chromatography</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Separation Science

ISSN

1615-9306

e-ISSN

1615-9314

Volume of the periodical

45

Issue of the periodical within the volume

17

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

3319-3327

UT code for WoS article

000832553700001

EID of the result in the Scopus database

2-s2.0-85135037112