Beyond pH: Acid/Base Relationships in Frozen and Freeze-Dried Pharmaceuticals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00131885" target="_blank" >RIV/00216224:14310/23:00131885 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007/978-3-031-12634-5_3" target="_blank" >https://link.springer.com/chapter/10.1007/978-3-031-12634-5_3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-12634-5_3" target="_blank" >10.1007/978-3-031-12634-5_3</a>

Result language
angličtina
Original language name
Beyond pH: Acid/Base Relationships in Frozen and Freeze-Dried Pharmaceuticals
Original language description
Stability of the majority of pharmaceuticals and biopharmaceuticals depends on acidity/basicity of the environment. In aqueous solutions, acidity/basicity is commonly expressed using proton activity scale, pH, while definition and experimental measurements of acid-base relationships in frozen and freeze-dried materials are less straightforward. The chapter starts with a brief summary of the current understanding of several critical aspects of pH and apparent acidity/basicity as related to freezing and freeze-drying, whereas the main part of the chapter is focused on areas which are underrepresented in the pharmaceutical literature, with both overview of the literature and previously unpublished data presented. In particular, the following topics are covered: (i) Hammett acidity function and pH-equivalent (pHeq); (ii) Factors which impact apparent solid-state acidity in lyophiles; (iii) Solid-state acidity and chemical instability of lyophiles; (iv) Freezing fundamentals: quasi-liquid layer, polarity of the freeze-concentrated solution, and the Workman-Reynolds potential. Potential directions for future studies in this field are also outlined.
Czech name
—
Czech description
—

Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Principles and Practices of Lyophilization in Product Development and Manufacturing - AAPS Advances in the Pharmaceutical Sciences Series
ISBN
9783031126338
Number of pages of the result
23
Pages from-to
39-61
Number of pages of the book
623
Publisher name
Springer Nature
Place of publication
Cham
UT code for WoS chapter
—

Similar results(10)