All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00132340" target="_blank" >RIV/00216224:14310/23:00132340 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.3390/ecsoc-27-16142" target="_blank" >https://doi.org/10.3390/ecsoc-27-16142</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ecsoc-27-16142" target="_blank" >10.3390/ecsoc-27-16142</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

  • Original language description

    The phylum Proteobacteria, more precisely the family Enterobacteriacea, has been shown to be a major cause of inflammation in the human microbiome. Their standard level in the human intestine is usually kept below 1% in a healthy person, and their overgrowth above this number leads to intestinal inflammation, which can cause the development of inflammatory bowel diseases - most often Crohn's disease or ulcerative colitis. The minimum inhibitory concentrations (MICs) of a series of eighteen recently synthesized N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides were determined against two representatives of the Enterobacteriaceae family – Escherichia coli CCM 3954 and Salmonella typhimurium LT 2-18. Although the tested compounds are cyclic analogs of salicylanilides known to have strong antimicrobial properties, the minimum inhibitory concentrations found were in the range between 50 µM and 1000 µM. However, it can be concluded that S. typhimurium was generally more sensitive to the tested antimicrobial agents than E .coli. N-[2-(But-2-yloxy)phenyl]-1-hydroxynaphthalene-2-carboxamide was the most active of the compounds with an MIC of 100 µM against pro E. coli and an MIC of 50 µM against S. typhimurium.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    The 27th International Electronic Conference on Synthetic Organic Chemistry

  • ISBN

  • ISSN

    2673-4583

  • e-ISSN

    2673-4583

  • Number of pages

    5

  • Pages from-to

    1-5

  • Publisher name

    MDPI

  • Place of publication

    Basel

  • Event location

    on-line, Basel, Švýcarsko

  • Event date

    Nov 15, 2023

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article