Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F24%3A00136012" target="_blank" >RIV/00216224:14310/24:00136012 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1126/sciadv.adk1954" target="_blank" >https://doi.org/10.1126/sciadv.adk1954</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.adk1954" target="_blank" >10.1126/sciadv.adk1954</a>
Alternative languages
Result language
angličtina
Original language name
Structure and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi
Original language description
The globally distributed marine alga Emiliania huxleyi has cooling effect on the Earth's climate. The population density of E. huxleyi is restricted by Nucleocytoviricota viruses, including E. huxleyi virus 201 (EhV-201). Despite the impact of E. huxleyi viruses on the climate, there is limited information about their structure and replication. Here, we show that the dsDNA genome inside the EhV-201 virion is protected by an inner membrane, capsid, and outer membrane. EhV-201 virions infect E. huxleyi by using fivefold vertices to bind to and fuse the virus' inner membrane with the cell plasma membrane. Progeny virions assemble in the cytoplasm at the surface of endoplasmic reticulum-derived membrane segments. Genome packaging initiates synchronously with the capsid assembly and completes through an aperture in the forming capsid. The genome-filled capsids acquire an outer membrane by budding into intracellular vesicles. EhV-201 infection induces a loss of surface protective layers from E. huxleyi cells, which enables the continuous release of virions by exocytosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science advances
ISSN
2375-2548
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1-13
UT code for WoS article
001200693100008
EID of the result in the Scopus database
2-s2.0-85190435170