Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F24%3A00136678" target="_blank" >RIV/00216224:14310/24:00136678 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.est.3c07961" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.est.3c07961</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.est.3c07961" target="_blank" >10.1021/acs.est.3c07961</a>
Alternative languages
Result language
angličtina
Original language name
Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding
Original language description
Through investigating the combined impact of the environmental exposures experienced by an individual throughout their lifetime, exposome research provides opportunities to understand and mitigate negative health outcomes. While current exposome research is driven by epidemiological studies that identify associations between exposures and effects, new frameworks integrating more substantial population-level metadata, including electronic health and administrative records, will shed further light on characterizing environmental exposure risks. Molecular biology offers methods and concepts to study the biological and health impacts of exposomes in experimental and computational systems. Of particular importance is the growing use of omics readouts in epidemiological and clinical studies. This paper calls for the adoption of mechanistic molecular biology approaches in exposome research as an essential step in understanding the genotype and exposure interactions underlying human phenotypes. A series of recommendations are presented to make the necessary and appropriate steps to move from exposure association to causation, with a huge potential to inform precision medicine and population health. This includes establishing hypothesis-driven laboratory testing within the exposome field, supported by appropriate methods to read across from model systems research to human.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN
0013-936X
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
7256-7269
UT code for WoS article
001244386100001
EID of the result in the Scopus database
2-s2.0-85191174239