Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F24%3A00136706" target="_blank" >RIV/00216224:14310/24:00136706 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1438463924000592?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1438463924000592?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijheh.2024.114378" target="_blank" >10.1016/j.ijheh.2024.114378</a>

Result language

angličtina

Original language name

Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU

Original language description

Phthalates and the substitute plasticizer DINCH belong to the first group of priority substances investigated by the European Human Biomonitoring Initiative (HBM4EU) to answer policy -relevant questions and safeguard an efficient science -to -policy transfer of results. Human internal exposure levels were assessed using two data sets from all European regions and Israel. The first collated existing human biomonitoring (HBM) data (2005 -2019). The second consisted of new data generated in the harmonized "HBM4EU Aligned Studies " (2014 -2021) on children and teenagers for the ten most relevant phthalates and DINCH, accompanied by a quality assurance/ quality control (QA/QC) program for 17 urinary exposure biomarkers. Exposures differed between countries, European regions, age groups and educational levels. Toxicologically derived Human biomonitoring guidance values (HBM-GVs) were exceeded in up to 5% of the participants of the HBM4EU Aligned Studies. A mixture risk assessment (MRA) including five reprotoxic phthalates (DEHP, DnBP, DiBP, BBzP, DiNP) revealed that for about 17% of the children and teenagers, health risks cannot be excluded. Concern about male reproductive health emphasized the need to include other anti -androgenic substances for MRA. Contaminated food and the use of personal care products were identified as relevant exposure determinants paving the way for new regulatory measures. Time trend analyses verified the efficacy of regulations: especially for the highly regulated phthalates exposure dropped significantly, while levels of the substitutes DINCH and DEHTP increased. The HBM4EU ewaste study, however, suggests that workers involved in e -waste management may be exposed to higher levels of restricted phthalates. Exposure -effect association studies indicated the relevance of a range of endpoints. A set of HBM indicators was derived to facilitate and accelerate science -to -policy transfer. Result indicators allow different groups and regions to be easily compared. Impact indicators allow health risks to be directly interpreted. The presented results enable successful science -to -policy transfer and support timely and targeted policy measures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Hygiene and Environmental Health

ISSN

1438-4639

e-ISSN

—

Volume of the periodical

259

Issue of the periodical within the volume

June 2024

Country of publishing house

DE - GERMANY

Number of pages

15

Pages from-to

1-15

UT code for WoS article

001230730500001

EID of the result in the Scopus database

2-s2.0-85190319313