Biomarker responses in wild brown trout from a headwater stream and their causal link to water pollution assessed through chemical analysis and in vitro reporter gene bioassays

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F25%3A00141581" target="_blank" >RIV/00216224:14310/25:00141581 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12520/25:43909697

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0304389425013482?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304389425013482?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jhazmat.2025.138433" target="_blank" >10.1016/j.jhazmat.2025.138433</a>

Result language

angličtina

Original language name

Biomarker responses in wild brown trout from a headwater stream and their causal link to water pollution assessed through chemical analysis and in vitro reporter gene bioassays

Original language description

Improving our understanding of how environmental pollution affects aquatic life requires a holistic approach. This study provides new insights into the intrinsic biological defence of brown trout (Salmo trutta m. fario L.) against chemical pollution in a stream with a low-dilution factor, a common scenario in headwaters globally. Fish restocked downstream of a sewage treatment plant (STP) were compared with a control group upstream of STP. Trout tissues were sampled after 6, 14, and 24 weeks and subjected to biochemical and histological analyses. Passive samplers were deployed at both stream stretches to reflect concentrations of freely dissolved organic micropollutants and their bioactivity effects using in vitro reporter gene bioassays. Chemical analysis downstream revealed elevated concentrations of micropollutants compared to upstream. In vitro bioassays detected increased androgenicity, estrogenicity, and transthyretin-binding inhibition. Antioxidant and biotransformation enzyme activities in fish indicated gradual acclimation to pollution despite minor histopathological changes. Elevated vitellogenin and 17 beta-estradiol in males suggested pollution-induced endocrine disruption. Although the results obtained from water chemical profiling and bioassays have a causal relationship to fish health, trout's molecular defence system allowed gradual acclimation to pollution, mitigating broader ecological impacts. The study advanced the knowledge of how fish cope with wastewater-borne micropollutants in aquatic environments. vitellogenin and 17 beta-estradiol in males suggested pollution-induced endocrine disruption. Although the results obtained from water chemical profiling and bioassays have a causal relationship to fish health, trout's molecular defence system allowed gradual acclimation to pollution, mitigating broader ecological impacts. The study advanced the knowledge of how fish cope with wastewater-borne micropollutants in aquatic environments.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

<a href="/en/project/GX20-04676X" target="_blank" >GX20-04676X: Holistic exposure and effect potential assessment of complex chemical mixtures in the aquatic environment</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Hazardous Materials

ISSN

0304-3894

e-ISSN

1873-3336

Volume of the periodical

494

Issue of the periodical within the volume

August 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

19

Pages from-to

1-19

UT code for WoS article

001485930700002

EID of the result in the Scopus database

2-s2.0-105004175406