Haplotype analysis of the region of 6p chromosome spanning the AGER ? TNFA ? LTA ? NFKBIL1 ? BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F06%3A00015475" target="_blank" >RIV/00216224:14330/06:00015475 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Haplotype analysis of the region of 6p chromosome spanning the AGER ? TNFA ? LTA ? NFKBIL1 ? BAT1 loci: Preliminary results of association study with diabetic nephropathy and retinopathy
Original language description
Aims: Previously we identified RAGE2 haplotype in the AGER gene as a risk factor for diabetic nephropathy (DN) and single nucleotide polymorphism (SNP) 252A/G in the LTA gene as a risk factor for both DN and proliferative diabetic retinopathy (PDR). Recently, multiple SNPs in the BAT1, NFKBIL1 and LTA genes have been found associated with myocardial infarction in the genome-wide association study. Detail analysis of the given MHC III region on chromosome 6p spanning the AGER ? TNFA ? LTA ? NFKBIL1 ? BAT1 loci could further elucidate the character of association and help to identify causal variant. The aims of the study were (1) to construct haplotypes based on genotypes of 13 SNPs in the five genes analysed and (2) to ascertain eventual association ofceratin haplotype(s) with DN and/or PDR. Methods: A total of 981 subjects comprising four groups (DM+DN, DM+PDR, DM without complications and non-DM) were included in the study. Genotypes were detected with PCR-based methodology.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů