Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F06%3A00018067" target="_blank" >RIV/00216224:14330/06:00018067 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analysis
Original language description
MULTIPLE MYELOMA (MM) is characterized by monoclonal proliferation of plasma cells and represents approximately 10% of all hematologic malignancies. The clinical course of patients with MM is highly variable. Reliable genetic indicators are therefore required for their stratification and for more adequate therapy. The metaphase cytogenetic studies in MM are hampered by a low proliferative activity of myeloma cells in vitro. Therefore, interphase fluorescent in situ hybridization (I-FISH) using specificDNA probes is the technique of choice for the determination of genomic aberrations associated with this disease. However, I-FISH on bone marrow specimens do not distinguish malignant plasma cells. In order to solve this problem, various novel techniqueshave been designated for selection of myeloma cells. Immunofluorescent labelling of malignant plasma cells is suitable approach for the diagnosis of chromosomal abnormalities in patients with MM. This method allows selection of monotypic
Czech name
Technika imunofluoresenčního znační klonálních plazmatických buněk u mnohočetného myelomu a FISH
Czech description
Práce se zabývá identifikací plazmatických buněk u mnohočetného myelomu pomocí imunofluorescenčního barvení cytoplazmatických imunoglobulínů v kombinaci s technikou FISH.
Classification
Type
D - Article in proceedings
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR8183" target="_blank" >NR8183: Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Detection of chromosomal aberrations in multiple myeloma
ISBN
80-210-4129-3
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
16
Publisher name
Masaryk University
Place of publication
Brno
Event location
Brno, ILBIT MU, Kamenice 5
Event date
Oct 25, 2006
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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