Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F06%3A00040704" target="_blank" >RIV/00216224:14330/06:00040704 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells
Original language description
Microarrays technology is a very powerful tool for monitoring gene expression. In our experiments with CD34+ differentiation assays, we used Transcription density map (TDM) as a new tool for evaluation of expression patterns in enriched populations of different cell lineages. Hematopoietic stem cells (enriched in fraction of CD34+ cells) have the ability to regenerate hematopoiesis. This potential is clinically used in transplanting bone marrow or peripheral blood stem cells. TDM is an improved transcription map. Genes are mapped on chromosomes according to their offset in basepairs (instead of sequential ordering used by traditional transcription maps (TMs)). TDM clearly and exactly shows the differences in expression patterns of evaluated populations. We can see the differences in expression level between individual genes and also between gene families or chromosome regions.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1A8241" target="_blank" >1A8241: New possibilities of diagnostics of leukemia using DNA-microarrays</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů