In silico search for secondary structures in p53 target genes using R/Bioconductor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F13%3A00068953" target="_blank" >RIV/00216224:14330/13:00068953 - isvavai.cz</a>
Result on the web
<a href="https://www.researchgate.net/publication/254257375_In_silico_search_for_secondary_structures_in_p53_target_genes_using_RBioconductor?ev=prf_pub" target="_blank" >https://www.researchgate.net/publication/254257375_In_silico_search_for_secondary_structures_in_p53_target_genes_using_RBioconductor?ev=prf_pub</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In silico search for secondary structures in p53 target genes using R/Bioconductor
Original language description
p53 is a well-known transcription factor and tumor suppressor, regulating among other processes, the commitment of cells to apoptosis and DNA repair. p53 mutants are often found in cancers of different kinds, ei- ther as mutant or misregulated p53. p53 is involved in many other processes and we currently do not understand the full range of its functions. It is known to recognize the p53con sequence by its specific DNA-binding domain (DBD). It is also known to bind DNA non-specifically. This binding hasbeen shown to involve superhelical DNA, more specifically, cruciform, triplex and quadruplex struc- tures. In our laboratories we were intrigued by the possi- ble interplay between non-canonical DNA structure bind- ing and regular p53con binding. In an attempt to clarify this interplay and discover suitable candidate genes for fur- ther study, we carried out an in silico study on the human genome.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
IN - Informatics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LG13010" target="_blank" >LG13010: Czech Republic representation in the European Research Consortium for Informatics and Mathematics (ERCIM)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
ITAT 2013: Information Technologies - Applications and Theory (Workshops, Posters, and Tutorials)
ISBN
149095208X
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
42-46
Publisher name
CreateSpace Independent Publishing Platform
Place of publication
Neuvedeno
Event location
Donovaly, SVK
Event date
Sep 11, 2013
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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