Hematopoietic differentiation of human pluripotent stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F14%3A00074041" target="_blank" >RIV/00216224:14330/14:00074041 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Hematopoietic differentiation of human pluripotent stem cells
Original language description
Generation of desired cell types from human pluripotent stem cells (hPSCs) promise many applications in regenerative medicine, e.g. in vitro generated hematopoietic progenitors could provide an alternative to hematopoietic stem cells used for transplantations. However, current protocols for hematopoietic differentiation of hPSCs suffer from low efficiency and functional defects in the derived cells. The technology is also limited by an unequal capacity of various hPSC lines to generate hematopoietic progenitors, which could be reasoned by genetic and epigenetic variations of hPSCs. Methodologies for hematopoietic differentiation in feeder-free conditions were applied to available human embryonic stem cell (hESC) and human induced pluripotent stem cell(hiPSC) lines in this study to determine their hematopoietic differentiation potential.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů