Parameter Synthesis by Model Checking in Formal Biochemical Space
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F15%3A00084271" target="_blank" >RIV/00216224:14330/15:00084271 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Parameter Synthesis by Model Checking in Formal Biochemical Space
Original language description
Many quantitative dynamical models in computational systems biology are represented in the form of ordinary differential equations. Most of them are based on known first principles and are highly parametrized. Suitable wet-lab measurements and existing hypotheses about the modelled phenomena can be represented in a temporal logic and considered as constraints for the admissible parameters. Model checking and monitoring techniques known from formal verification can be used to synthesise model parametersthat guarantee a given set of temporal properties. In this talk we present the scalable coloured model checking approach for parameter synthesis from LTL and CTL specifications. The method will be presented in the context of formal biochemical space thatattempts to avoid the gap between formal methods and biology. On the practical side, application of the method to several biological problems will be given.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
IN - Informatics
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů