RNA-dependent disassembly of nuclear bodies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F16%3A00087720" target="_blank" >RIV/00216224:14330/16:00087720 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1242/jcs.189142" target="_blank" >http://dx.doi.org/10.1242/jcs.189142</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/jcs.189142" target="_blank" >10.1242/jcs.189142</a>
Alternative languages
Result language
angličtina
Original language name
RNA-dependent disassembly of nuclear bodies
Original language description
Nuclear bodies are membraneless organelles that play important roles in genome functioning. A specific type of nuclear bodies known as interphase prenucleolar bodies (iPNBs) are formed in the nucleoplasm after hypotonic stress from partially disassembled nucleoli. iPNBs are then disassembled, and the nucleoli are reformed simultaneously. Here, we show that diffusion of B23 molecules (also known as nucleophosmin, NPM1) from iPNBs, but not fusion of iPNBs with the nucleoli, contributes to the transfer of B23 from iPNBs to the nucleoli. Maturation of pre-ribosomal RNAs (rRNAs) and the subsequent outflow of mature rRNAs from iPNBs led to the disassembly of iPNBs. We found that B23 transfer was dependent on the synthesis of pre-rRNA molecules in nucleoli; these pre-rRNA molecules interacted with B23 and led to its accumulation within nucleoli.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cell Science
ISSN
0021-9533
e-ISSN
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Volume of the periodical
129
Issue of the periodical within the volume
24
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
4509-4520
UT code for WoS article
000391103700008
EID of the result in the Scopus database
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