Tasks and Visual Abstractions for 3D Chromatin Representation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F25%3A00141654" target="_blank" >RIV/00216224:14330/25:00141654 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/cgf.70142?af=R" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/cgf.70142?af=R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cgf.70142" target="_blank" >10.1111/cgf.70142</a>
Alternative languages
Result language
angličtina
Original language name
Tasks and Visual Abstractions for 3D Chromatin Representation
Original language description
The spatial organization of chromatin fiber directly influences its function. However, the high visual complexity of chromatin spatial models makes the understanding of the structure extremely challenging. Therefore, genomic researchers still primarily rely on indirect analysis of chromatin through 2D views, missing the advantages that 3D visualization can offer. In this paper, we first analyze the task space of genomic research and identify biological domain tasks that can benefit from dedicated spatial representations. We organize these tasks into four categories: tasks related to structural features, additional meta-data, structural relationships, and comparative tasks. We analyze these tasks in terms of their complexity, co-dependence, and potential benefits of 3D-based solutions. Secondly, we present four newly designed visual representations of chromatin 3D structure, focused on enhancing the understanding of structural features and solving relationships tasks. These include the hierarchical nature of spatial chromatin sub-units, their visual abstractions, spatial interactions, and a cumulative representation of chromatin dynamic behavior. We also include feedback from four domain researchers and discuss future steps necessary to make spatial representations valid and valuable part of genomic research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
<a href="/en/project/GA23-05651S" target="_blank" >GA23-05651S: ChromeXplore: Interactive visual exploration of chromatin</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
COMPUTER GRAPHICS FORUM
ISSN
0167-7055
e-ISSN
1467-8659
Volume of the periodical
44
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1-12
UT code for WoS article
001493195800001
EID of the result in the Scopus database
2-s2.0-105005799251