The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00050036" target="_blank" >RIV/00216224:14740/11:00050036 - isvavai.cz</a>

Result on the web

<a href="http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2011.047" target="_blank" >10.5507/bp.2011.047</a>

Result language

angličtina

Original language name

The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver

Original language description

We previously reported the effect of St John?s wort (Hypericum perforatum) standardised extract LI 160 on the activities of cytochrome P450 2C6, 2D2 and 3As (Dostalek et al., Life Sciences 2005;78(3):239-44). In this study, we aimed to assess the effectof St John?s wort on the activity of cytochrome P450 1A2. The isolated perfused rat liver model was used in our experiments with phenacetin as a marker substrate for cytochrome P450 1A2. The rate of formation of acetaminophen was significantly inhibitedby the use of St John?s wort. In addition, St John's wort extract inhibited cytochrome P450 1A2 activity significantly more than the control inhibitor. St John?s wort significantly inhibited cytochrome P450 1A2 enzyme activity. It remains to be determined whether the co-administration of St John's wort extract and other medications or substrates for cytochrome P450 1A2 could result in significant drug interactions.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic

ISSN

1213-8118

e-ISSN

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Volume of the periodical

155

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

253-257

UT code for WoS article

000297807500005

EID of the result in the Scopus database

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