Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00065560" target="_blank" >RIV/00216224:14740/11:00065560 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2011.01639.x/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0609.2011.01639.x/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1600-0609.2011.01639.x" target="_blank" >10.1111/j.1600-0609.2011.01639.x</a>

Result language

angličtina

Original language name

Modern and conventional prognostic markers of chronic lymphocytic leukemia in the everyday haematological practice

Original language description

Objectives: The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Haematology

ISSN

0902-4441

e-ISSN

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Volume of the periodical

87

Issue of the periodical within the volume

2

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

130-137

UT code for WoS article

000292778800005

EID of the result in the Scopus database

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