Cyclin K goes with Cdk12 and Cdk13

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00057443" target="_blank" >RIV/00216224:14740/12:00057443 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/12:#0000936
Result on the web
<a href="http://www.celldiv.com/content/7/1/12" target="_blank" >http://www.celldiv.com/content/7/1/12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1747-1028-7-12" target="_blank" >10.1186/1747-1028-7-12</a>

Result language
angličtina
Original language name
Cyclin K goes with Cdk12 and Cdk13
Original language description
The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins? functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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