MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00062179" target="_blank" >RIV/00216224:14740/12:00062179 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
MicroRNAs are promising biomarkers and therapeutic targets in high-grade gliomas
Original language description
High-grade gliomas are highly malignant primary brain tumors of supportive glial cells origin. Despite optimal course of treatment, including maximal surgical resection followed by chemo- and/orradiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo-radioresistance that is manifested by early progression after or even during oncology treatment. Accurate prediction of therapy response and adjuvant therapeutic approach enabling an overcoming of resistance consist the main aims of glioma translationalresearch. The important role in therapeutic resistance play cancer stem cells (CSCs) and thus, signaling pathways related to maintaining stem-like phenotype. Glioma stem cells (GSCs) are associated with time to progression and overall survival of glioma patients. In recent years, it was shown that biological features of GSCs could be effectively regulated by microRNAs (miRNAs), short endogenou RNA molecules that post-transcriptionally regulate gene expr
Czech name
—
Czech description
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)