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Dystonia and the cerebellum: A new field of interest in movement disorders?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065623" target="_blank" >RIV/00216224:14740/13:00065623 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.ncbi.nlm.nih.gov/pubmed/23422326" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/23422326</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clinph.2013.01.003" target="_blank" >10.1016/j.clinph.2013.01.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dystonia and the cerebellum: A new field of interest in movement disorders?

  • Original language description

    Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Neurophysiology

  • ISSN

    1388-2457

  • e-ISSN

  • Volume of the periodical

    124

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    8

  • Pages from-to

    1269-1276

  • UT code for WoS article

    000321488200006

  • EID of the result in the Scopus database