Dystonia and the cerebellum: A new field of interest in movement disorders?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065623" target="_blank" >RIV/00216224:14740/13:00065623 - isvavai.cz</a>
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/23422326" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/23422326</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinph.2013.01.003" target="_blank" >10.1016/j.clinph.2013.01.003</a>
Alternative languages
Result language
angličtina
Original language name
Dystonia and the cerebellum: A new field of interest in movement disorders?
Original language description
Although dystonia has traditionally been regarded as a basal ganglia dysfunction, recent provocative evidence has emerged of cerebellar involvement in the pathophysiology of this enigmatic disease. This review synthesizes the data suggesting that the cerebellum plays an important role in dystonia etiology, from neuroanatomical research of complex networks showing that the cerebellum is connected to a wide range of other central nervous system structures involved in movement control to animal models indicating that signs of dystonia are due to cerebellum dysfunction and completely disappear after cerebellectomy, and finally to clinical observations in secondary dystonia patients with various types of cerebellar lesions. We propose that dystonia is a large-scale dysfunction, involving not only cortico-basal ganglia-thalamo-cortical pathways, but the cortico-ponto-cerebello-thalamo-cortical loop as well.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurophysiology
ISSN
1388-2457
e-ISSN
—
Volume of the periodical
124
Issue of the periodical within the volume
7
Country of publishing house
IE - IRELAND
Number of pages
8
Pages from-to
1269-1276
UT code for WoS article
000321488200006
EID of the result in the Scopus database
—