EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065638" target="_blank" >RIV/00216224:14740/13:00065638 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma
Original language description
Renal cell carcinoma (RCC) belongs among the most common adult kidney neoplasm. Because of the lack of early warning signals, a high percentage of patients with metastatic RCC occur. Nowadays, epithelial-mesenchymal transition (EMT) as a crucial event ofthe tumor progression resulting in metastasis is intensively studied. EMT is a biological process in which polarized epithelial cells undergo multiple biochemical changes altering their phenotype from epithelial to mesenchymal. This phenotype change observed during the tumor metastasis development is also accompanied on a molecular level by miRNAs deregulation. In our study, we try to identify EMT-related miRNAs that can be used in clinical practice as a predictors of metastatic risk and early relapseof the RCC. Five EMT-related miRNAs were studied on 3 different groups of RCC patients.
Czech name
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Czech description
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Project
<a href="/en/project/NT13547" target="_blank" >NT13547: Study od epithelial-to-mesenchymal transition associated microRNAs and genes as potential markers for prediction of risk and early detection of metastatic disease in renal cell carcinoma patients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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