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Endocannabinoid system and mood disorders: Priming a target for new therapies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00067765" target="_blank" >RIV/00216224:14740/13:00067765 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0163725812002409" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0163725812002409</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.pharmthera.2012.12.002" target="_blank" >10.1016/j.pharmthera.2012.12.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Endocannabinoid system and mood disorders: Priming a target for new therapies

  • Original language description

    The endocannabinoid system (ECS), comprising two G protein-coupled receptors (the cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle delta 9-tetrahydrocannabinol [delta 9-THC]), their endogenous small lipid ligands (namelyanandamide [AEA] and 2-arachidonoylglycerol [2-AG], also known as endocannabinoids), and the proteins for endocannabinoid biosynthesis and degradation, has been suggested as a pro-homeostatic and pleiotropic signaling system activated in a time- and tissue-specific way during physiopathological conditions. In the brain activation of this system modulates the release of excitatory and inhibitory neurotransmitters and of cytokines from glial cells. As such, the ECS is strongly involved in neuropsychiatric disorders, particularly in affective disturbances such as anxiety and depression.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pharmacology & Therapeutics

  • ISSN

    0163-7258

  • e-ISSN

  • Volume of the periodical

    138

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    20

  • Pages from-to

    18-37

  • UT code for WoS article

    000316520600002

  • EID of the result in the Scopus database