Endocannabinoid system and mood disorders: Priming a target for new therapies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00067765" target="_blank" >RIV/00216224:14740/13:00067765 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0163725812002409" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0163725812002409</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pharmthera.2012.12.002" target="_blank" >10.1016/j.pharmthera.2012.12.002</a>
Alternative languages
Result language
angličtina
Original language name
Endocannabinoid system and mood disorders: Priming a target for new therapies
Original language description
The endocannabinoid system (ECS), comprising two G protein-coupled receptors (the cannabinoid receptors 1 and 2 [CB1 and CB2] for marijuana's psychoactive principle delta 9-tetrahydrocannabinol [delta 9-THC]), their endogenous small lipid ligands (namelyanandamide [AEA] and 2-arachidonoylglycerol [2-AG], also known as endocannabinoids), and the proteins for endocannabinoid biosynthesis and degradation, has been suggested as a pro-homeostatic and pleiotropic signaling system activated in a time- and tissue-specific way during physiopathological conditions. In the brain activation of this system modulates the release of excitatory and inhibitory neurotransmitters and of cytokines from glial cells. As such, the ECS is strongly involved in neuropsychiatric disorders, particularly in affective disturbances such as anxiety and depression.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacology & Therapeutics
ISSN
0163-7258
e-ISSN
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Volume of the periodical
138
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
18-37
UT code for WoS article
000316520600002
EID of the result in the Scopus database
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