The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00068050" target="_blank" >RIV/00216224:14740/13:00068050 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.hoc.2012.12.001" target="_blank" >http://dx.doi.org/10.1016/j.hoc.2012.12.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.hoc.2012.12.001" target="_blank" >10.1016/j.hoc.2012.12.001</a>

Result language
angličtina
Original language name
The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia
Original language description
Roughly 30% of patients with chronic lymphocytic leukemia (CLL) carry immunoglobulin receptors with highly similar primary sequences. Highly similar, quasi-identical immunoglobulins are termed stereotyped. Patients with CLL can be assigned to different subsets expressing different types of stereotyped immunoglobulin receptors. Reliable identification of stereotypy may assist in the molecular classification of CLL and thus better-guided, compartmentalized research. In several major subsets, stereotypy extends from shared primary sequences to shared clinicobiological features and outcome. Reliable identification of stereotypy in CLL may pave the way for tailored treatment strategies applicable to each major stereotyped subset.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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