Exploring the reaction mechanism for OGT glycosyltransferase using QM/MM molecular dynamics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072706" target="_blank" >RIV/00216224:14740/13:00072706 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Exploring the reaction mechanism for OGT glycosyltransferase using QM/MM molecular dynamics
Original language description
Carbohydrates play a pivotal role in a plethora of the biological processes as they are ubiquitously present in all cells in the variety of forms such as glycoproteins, proteoglycans and glycolipids collectively called as glyco-conjugates. Glyco-conjugates carry the necessary information for cell-cell recognition1 and their function is quite diverse and vital for the cell. These glyco-conjugates are formed by the sequential action of glycosyltransferases (GTase) which add saccharides onto proteins, lipids etc.2 Our present study is focused on the exploring the reaction mechanisms of O-GlcNAcylation process, where GlcNAc is transferred to ?OH group of Ser/Thr of the proteins. The aim of the study is to find the most probable reaction pathways and corresponding transition states. Several mechanisms for the OGT glycosyltransferase are already proposed on similar systems (Figure 1).
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů