Interactions of carbohydrates with biomolecules. Role of the CH/pi interactions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072707" target="_blank" >RIV/00216224:14740/13:00072707 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Interactions of carbohydrates with biomolecules. Role of the CH/pi interactions
Original language description
Molecular recognition plays crucial role in many biological processes, such as bacteria-host identification. Some of these recognition processes are performed by proteins called lectins, which are able to bind saccharides in a very specific way. In our study we have focused on RSL lectin from world-wide distributed bacteria Ralstonia solanacearum causing lethal wilt in many agricultural crops and the AAL lectin from Aleuria aurantia. Both above mentioned bacteria interact with hosts through their lectins, binding predominantly L-fucose. In this paper, we are interested in the role of the CH/pi interaction in binding abilities of these two lectins. In the RSL lectin, we have attempted for the first time to quantify how the CH/pi interaction contributesto a overall carbohydrate - protein interaction. We have used an experimental approach, creating single and double point mutants, combined with high level computational methods.
Czech name
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Czech description
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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