Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072871" target="_blank" >RIV/00216224:14740/13:00072871 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-1-62703-269-8_8" target="_blank" >http://dx.doi.org/10.1007/978-1-62703-269-8_8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-62703-269-8_8" target="_blank" >10.1007/978-1-62703-269-8_8</a>

Result language
angličtina
Original language name
Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas
Original language description
Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, ?stereotyped? immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequenceswithin their B cell receptors (BcR), suggesting selection by common epitopes or classes of structurally similar epitopes. BcR stereotypy was initially described in chronic lymphocytic leukemia (CLL), where it constitutes a remarkably frequent feature ofthe IG repertoire, and subsequently identified in other malignancies, including mantle cell lymphoma and splenic marginal-zone lymphoma. Of note, at least in CLL, emerging evidence indicates that the grouping of cases into distinct clusters with stereotyped BcR is functionally and prognostically relevant.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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