MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00074731" target="_blank" >RIV/00216224:14740/13:00074731 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10428194.2013.796055" target="_blank" >http://dx.doi.org/10.3109/10428194.2013.796055</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10428194.2013.796055" target="_blank" >10.3109/10428194.2013.796055</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia
Original language description
Abstract The relative expression levels of certain microRNAs (miRNAs) correlate with known prognostic markers in chronic lymphocytic leukemia (CLL), such as leukemia-cell expression of zeta-associated protein of 70 kDa (ZAP-70), use of unmutated immunoglobulin heavy-chain variable region genes (IGHV), chromosomal abnormalities or dysfunctional p53. Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups. How these miRNAsinfluence cellular activation and/or BCR signaling through the post-transcriptional regulation of critical signaling molecules (e.g. Lyn, Syk, BTK, SHIP-1, SHP1) is a topic of current research.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.30.0009" target="_blank" >EE2.3.30.0009: Employment of Newly Graduated Doctors of Science for Scientific Excellence</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LEUKEMIA & LYMPHOMA
ISSN
1042-8194
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
1836-1839
UT code for WoS article
000321763800051
EID of the result in the Scopus database
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