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Loss of loop adenines alters human telomere d(AG3(TTAG3)3) quadruplex folding

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00073361" target="_blank" >RIV/00216224:14740/14:00073361 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/14:00440266

  • Result on the web

    <a href="http://dx.doi.org/10.1093/nar/gku1245" target="_blank" >http://dx.doi.org/10.1093/nar/gku1245</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/nar/gku1245" target="_blank" >10.1093/nar/gku1245</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Loss of loop adenines alters human telomere d(AG3(TTAG3)3) quadruplex folding

  • Original language description

    Abasic (AP) lesions are the most frequent type of damages occurring in cellular DNA. Here we describe the conformational effects of AP sites substituted for 2'-deoxyadenosine in the first (ap7), second (ap13) or third (ap19) loop of the quadruplex formedin K+ by the human telomere DNA 5'-d[AG3(TTAG3)3]. CD spectra and electrophoresis reveal that the presence of AP sites does not hinder the formation of intramolecular quadruplexes. NMR spectra show that the structural heterogeneity is substantially reduced in ap7 and ap19 as compared to that in the wild-type. These two (ap7 and ap19) sequences are shown to adopt the hybrid-1 and hybrid-2 quadruplex topology, respectively, with AP site located in a propeller-like loop. All three studied sequences transform easily into parallel quadruplex in dehydrating ethanol solution. Thus, the AP site in any loop region facilitates the formation of the propeller loop.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nucleic Acids Research

  • ISSN

    0305-1048

  • e-ISSN

  • Volume of the periodical

    42

  • Issue of the periodical within the volume

    22

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    14031-14041

  • UT code for WoS article

    000347916900057

  • EID of the result in the Scopus database