Cell differentiation along multiple pathways accompanied by changes in histone acetylation status
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00073697" target="_blank" >RIV/00216224:14740/14:00073697 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00428044
Result on the web
<a href="http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VQAanuFFrs4" target="_blank" >http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2013-0082?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#.VQAanuFFrs4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1139/bcb-2013-0082" target="_blank" >10.1139/bcb-2013-0082</a>
Alternative languages
Result language
angličtina
Original language name
Cell differentiation along multiple pathways accompanied by changes in histone acetylation status
Original language description
Post-translational modification of histones is fundamental to the regulation of basic nuclear processes and subsequent cellular events, including differentiation. In this study, we analyzed acetylated forms of histones H2A, H2B, and H4 during induced differentiation in mouse (mESCs) and human (hESCs) embryonic stem cells and during induced enterocytic differentiation of colon cancer cells in vitro. Endoderm-like differentiation of mESCs induced by retinoic acid and enterocytic differentiation induced byhistone deacetylase inhibitor sodium butyrate were accompanied by increased mono-, di-, and tri-acetylation of histone H2B and a pronounced increase in di- and tri-acetylation of histone H4. In enterocytes, mono- acetylation of histone H2A also increased and tetra-acetylation of histone H4 appeared only after induction of this differentiation pathway. During differentiation of hESCs, we observed increased mono-acetylation and decreased tri-acetylation of H2B.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
ISSN
0829-8211
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
2
Country of publishing house
CA - CANADA
Number of pages
9
Pages from-to
85-93
UT code for WoS article
000334029200001
EID of the result in the Scopus database
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