53BP1: pro choice in DNA repair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00074404" target="_blank" >RIV/00216224:14740/14:00074404 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0962892413001554/1-s2.0-S0962892413001554-main.pdf?_tid=66e12f66-bb3a-11e4-abe9-00000aacb360&acdnat=1424682203_f8bd4c3cd228cef3ed42bebd7ad4b631" target="_blank" >http://ac.els-cdn.com/S0962892413001554/1-s2.0-S0962892413001554-main.pdf?_tid=66e12f66-bb3a-11e4-abe9-00000aacb360&acdnat=1424682203_f8bd4c3cd228cef3ed42bebd7ad4b631</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tcb.2013.09.003" target="_blank" >10.1016/j.tcb.2013.09.003</a>
Alternative languages
Result language
angličtina
Original language name
53BP1: pro choice in DNA repair
Original language description
The DNA damage response factor 53BP1 functions at the intersection of two major double strand break (DSB) repair pathways - promoting nonhomologous end-joining (NHEJ) and inhibiting homology-directed repair (HDR) - and integrates cellular inputs to ensure their timely execution in the proper cellular contexts. Recent work has revealed that 53BP1 controls 5' end resection at DNA ends, mediates synapsis of DNA ends, promotes the mobility of damaged chromatin, improves DSB repair in heterochromatic regions, and contributes to lethal mis-repair of DSBs in BRCA1-deficient cells. Here we review these aspects of 53BP1 and discuss new data revealing how 53BP1 is loaded onto chromatin and uses its interacting factors Rif1 and PTIP to promote NHEJ and inhibit HDR.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP205%2F12%2F0550" target="_blank" >GAP205/12/0550: Dynamics of shelterin complex assembly</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
TRENDS IN CELL BIOLOGY
ISSN
0962-8924
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
108-117
UT code for WoS article
000332498100003
EID of the result in the Scopus database
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