DNA and RNA Quadruplex-Binding Proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00074408" target="_blank" >RIV/00216224:14740/14:00074408 - isvavai.cz</a>
Result on the web
<a href="http://www.mdpi.com/1422-0067/15/10/17493" target="_blank" >http://www.mdpi.com/1422-0067/15/10/17493</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms151017493" target="_blank" >10.3390/ijms151017493</a>
Alternative languages
Result language
angličtina
Original language name
DNA and RNA Quadruplex-Binding Proteins
Original language description
Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes which are featured by Hoogsteen base-paring. Sequences with the potential to form quadruplexes are widely present in genome of all organisms. They are found often in repetitive sequences such as telomeric ones, and also in promoter regions and 5' non-coding sequences. Recently, many proteins with binding affinity to G-quadruplexes have been identified. One of the initially portrayed G-rich regions, the human telomeric sequence (TTAGGG)(n), is recognized by many proteins which can modulate telomerase activity. Sequences with the potential to form G-quadruplexes are often located in promoter regions of various oncogenes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Center of novel approaches to bioanalysis and molecular diagnostics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
25
Pages from-to
17493-17517
UT code for WoS article
000348039400008
EID of the result in the Scopus database
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