Towards error-free profiling of immune repertoires

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00078399" target="_blank" >RIV/00216224:14740/14:00078399 - isvavai.cz</a>
Result on the web
<a href="http://www.nature.com/nmeth/journal/v11/n6/full/nmeth.2960.html" target="_blank" >http://www.nature.com/nmeth/journal/v11/n6/full/nmeth.2960.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/NMETH.2960" target="_blank" >10.1038/NMETH.2960</a>

Result language
angličtina
Original language name
Towards error-free profiling of immune repertoires
Original language description
Deep profiling of antibody and T cell-receptor repertoires by means of high-throughput sequencing has become an attractive approach for adaptive immunity studies, but its power is substantially compromised by the accumulation of PCR and sequencing errors. Here we report MIGEC (molecular identifier groups-based error correction), a strategy for high-throughput sequencing data analysis. MIGEC allows for nearly absolute error correction while fully preserving the natural diversity of complex immune repertoires.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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