Effect of partial drug withdrawal on the lateralization of interictal epileptiform discharges and its relationship to surgical outcome in patients with hippocampal sclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00078425" target="_blank" >RIV/00216224:14740/14:00078425 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0920121114001673/1-s2.0-S0920121114001673-main.pdf?_tid=797862f4-9d92-11e4-a812-00000aacb35e&acdnat=1421421495_c68d82fef4a0e8b698546a7eb04d88a5" target="_blank" >http://ac.els-cdn.com/S0920121114001673/1-s2.0-S0920121114001673-main.pdf?_tid=797862f4-9d92-11e4-a812-00000aacb35e&acdnat=1421421495_c68d82fef4a0e8b698546a7eb04d88a5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eplepsyres.2014.06.009" target="_blank" >10.1016/j.eplepsyres.2014.06.009</a>

Result language
angličtina
Original language name
Effect of partial drug withdrawal on the lateralization of interictal epileptiform discharges and its relationship to surgical outcome in patients with hippocampal sclerosis
Original language description
Objective: To assess changes in the relative lateralization of interictal epileptiform discharges (IEDs) and interictal EEG prognostic value in terms of surgical outcome between periods with full medication (FMP) and reduced medication (RMP) in patientswith temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS). Methods: Interictal scalp EEGs of 43 patients were evaluated for the presence of IEDs separately in a waking state (WS) and sleeping state (SS) during FMP and RMP. In each period, patients were categorized as having unitemporal or bitemporal IEDs. Surgical outcome was classified at year 1 after surgery and at last follow-up visit as Engel I or Engel II-IV; and alternatively as completely seizure-free or not seizure-free. Results: There were significant changes in relative IED lateralization between FMP and RMP during SS. The representation of patients with unitemporal IEDs declined from 37 (86%) in FMP during SS to 25 (58%) in RMP during SS (p = 0.003).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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