Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00078951" target="_blank" >RIV/00216224:14740/14:00078951 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/bmri/2014/691041/" target="_blank" >http://www.hindawi.com/journals/bmri/2014/691041/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/691041" target="_blank" >10.1155/2014/691041</a>
Alternative languages
Result language
angličtina
Original language name
Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury
Original language description
Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines. The goal of the present study was to investigate expression of proinflammatory (IL-1b, TNFa) and anti-inflammatory cytokines (IL-4, IL-10) in activatedSchwann cells in relation to growing axons distal to crush injury of rat sciatic nerves. Seven days fromsciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43). The Schwann cells of naive sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines. In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion. The cytokinepositive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"nestránkováno"
UT code for WoS article
000335836400001
EID of the result in the Scopus database
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