Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00081336" target="_blank" >RIV/00216224:14740/15:00081336 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/15:00455955

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0300908415002217" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0300908415002217</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biochi.2015.07.013" target="_blank" >10.1016/j.biochi.2015.07.013</a>

Result language

angličtina

Original language name

Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex

Original language description

Various base lesions continuously form in cellular nucleic acids and the unrepaired lesions are promutagenic and procarcinogenic. Though natural base lesions have been extensively studied in double-stranded DNA models, these studies are only less than adecade old for non-canonical DNA models, such as quadruplexes. Here we present a report on the effects of three frequently occurring natural lesions that can form in the TTA loops on the structure of the human telomere quadruplex d[AG(3)(TTAG(3))(3)]. Wecompared the effect of the abasic site and 8-oxoadenine replacing adenine and 5-hydroxymethyluracil substituting for thymine. The results showed that the three lesions impacted the stability and quadruplex folding in markedly different ways. The effectsdepended on the type of lesion and the position in the sequence. Analogous lesions of guanine in the G-tetrads extensively destabilized the quadruplex and the effects depended more on the position than on the type of lesion.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochimie

ISSN

0300-9084

e-ISSN

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Volume of the periodical

118

Issue of the periodical within the volume

Nov

Country of publishing house

FR - FRANCE

Number of pages

11

Pages from-to

15-25

UT code for WoS article

000365062200003

EID of the result in the Scopus database

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