Splenic marginal-zone lymphoma: ontogeny and genetics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00082264" target="_blank" >RIV/00216224:14740/15:00082264 - isvavai.cz</a>
Result on the web
<a href="http://informahealthcare.com/doi/abs/10.3109/10428194.2014.919636" target="_blank" >http://informahealthcare.com/doi/abs/10.3109/10428194.2014.919636</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10428194.2014.919636" target="_blank" >10.3109/10428194.2014.919636</a>

Result language
angličtina
Original language name
Splenic marginal-zone lymphoma: ontogeny and genetics
Original language description
Splenic marginal-zone lymphoma (SMZL) is a rare tumor that has recently emerged as a prototype for how the interplay between genetics and environment shapes the natural history of lymphomas. Indeed, the recent identification of molecular immunogenetic subgroups within SMZL may prove to be relevant not only for the sub-classification of the disease but also for improved understanding of the underlying biology. In contrast to other B-cell lymphomas, SMZL lacks a characteristic genetic lesion, although themajority of cases harbor genomic aberrations, as recently revealed by high-throughput studies that identified recurrent genetic aberrations, several in pathways related to marginal-zone differentiation and B-cell signaling.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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