Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of alpha-Synuclein Overexpressing Transgenic Mouse Model of Parkinson?s Disease: A Pilot Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00083366" target="_blank" >RIV/00216224:14740/15:00083366 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs12640-015-9537-9" target="_blank" >http://link.springer.com/article/10.1007%2Fs12640-015-9537-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12640-015-9537-9" target="_blank" >10.1007/s12640-015-9537-9</a>

Result language

angličtina

Original language name

Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of alpha-Synuclein Overexpressing Transgenic Mouse Model of Parkinson?s Disease: A Pilot Study

Original language description

Evidence suggests that accumulation and aggregation of alpha-synuclein contribute to the pathogenesis of Parkinson's disease (PD). The aim of this study was to evaluate whether diffusion kurtosis imaging (DKI) will provide a sensitive tool for differentiating between alpha-synuclein-overexpressing transgenic mouse model of PD (TNWT-61) and wild-type (WT) littermates. This experiment was designed as a proof-of-concept study and forms a part of a complex protocol and ongoing translational research. Nine-month-old TNWT-61 mice and age-matched WT littermates underwent behavioral tests to monitor motor impairment and MRI scanning using 9.4 Tesla system in vivo. Tract-based spatial statistics (TBSS) and the DKI protocol were used to compare the whole brain white matter of TNWT-61 and WT mice.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurotoxicity research

ISSN

1029-8428

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

281-289

UT code for WoS article

000362028700001

EID of the result in the Scopus database

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