Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00084162" target="_blank" >RIV/00216224:14740/15:00084162 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/15:#0000687 RIV/65269705:_____/15:00063848

Result on the web

<a href="http://www.mdpi.com/1422-0067/16/10/23382" target="_blank" >http://www.mdpi.com/1422-0067/16/10/23382</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms161023382" target="_blank" >10.3390/ijms161023382</a>

Result language

angličtina

Original language name

Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Original language description

Serum microRNAs are emerging as a clinically useful tool for early and non-invasive detection of various cancer types including renal cell carcinoma (RCC). Based on our previous results, we performed the study to analyze circulating serum miR-378 and miR-210 in patients with various histological subtypes of RCC. RNA was purified from blood serum samples of 195 RCC patients and 100 healthy controls. The levels of miR-378 and miR-210 in serum were determined absolutely using quantitative real-time PCR. Pre- and postoperative levels of both microRNAs were compared in 20 RCC patients. Significantly increased serum levels of both miR-378 and miR-210 enabled to clearly distinguish RCC patients and healthy controls with 80% sensitivity and 78% specificity ifanalyzed in combination (p &lt; 0.0001), and their levels significantly decreased in the time period of three months after radical nephrectomy (p &lt; 0.0001). Increased level of miR-378 positively correlates with disease-free survival (p

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

23382-23389

UT code for WoS article

000364232100016

EID of the result in the Scopus database

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