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A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00085160" target="_blank" >RIV/00216224:14740/15:00085160 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.nature.com/doifinder/10.1038/nature16141" target="_blank" >http://www.nature.com/doifinder/10.1038/nature16141</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/nature16141" target="_blank" >10.1038/nature16141</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance.

  • Original language description

    T-cell receptor (TCR) signalling has a key role in determining T-cell fate. Precursor cells expressing TCRs within a certain low-affinity range for complexes of self-peptide and major histocompatibility complex (MHC) undergo positive selection and differentiate into naive T cells expressing a highly diverse self-MHC-restricted TCR repertoire. In contrast, precursors displaying TCRs with a high affinity for 'self' are either eliminated through TCR-agonist-induced apoptosis (negative selection) or restrained by regulatory T (Treg) cells, whose differentiation and function are controlled by the X-chromosome-encoded transcription factor Foxp3 (reviewed in ref. 2). Foxp3 is expressed in a fraction of self-reactive T cells that escape negative selection in response to agonist-driven TCR signals combined with interleukin 2 (IL-2) receptor signalling.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nature

  • ISSN

    0028-0836

  • e-ISSN

  • Volume of the periodical

    528

  • Issue of the periodical within the volume

    7580

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    "132"-"+"

  • UT code for WoS article

    000365606000063

  • EID of the result in the Scopus database