Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00088062" target="_blank" >RIV/00216224:14740/16:00088062 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/16:10326732 RIV/00209805:_____/16:N0000097 RIV/65269705:_____/16:00075969

Result on the web

<a href="http://cgp.iiarjournals.org/content/13/4/311.full.pdf+html" target="_blank" >http://cgp.iiarjournals.org/content/13/4/311.full.pdf+html</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer

Original language description

BACKGROUND: Primary tumor spread to the liver is the major cause of disease progression and death in patients with colorectal cancer (CRC). MicroRNAs (miRNAs) are small non-coding RNAs that are involved in cancer development and progression, but their role in metastasis has not been extensively investigated. MATERIALS AND METHODS: Firstly, expression profiling of 752 miRNAs in 20 primary tumors and their corresponding liver metastases was performed. Secondly, validation of the results was carried out on an independent cohort of 66 patients with metastatic CRC using reverse transcription-quantitative polymerase chain (RT-qPCR) reaction. RESULTS: In total, 33 miRNAs were found to be significantly deregulated in liver metastases compared to their primary tumors. Fifteen miRNAs were chosen for subsequent validation, which confirmed significantly reduced expression of miR-143, miR 10b, and miR-28-5p, and increased expression of miR 122, miR-122*, and miR 885-5p in the tissue of liver metastases.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Genomics & Proteomics

ISSN

1109-6535

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

311-316

UT code for WoS article

000379252600007

EID of the result in the Scopus database

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