NMR solution structure determination of large RNA-protein complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00088765" target="_blank" >RIV/00216224:14740/16:00088765 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0079656516300310" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0079656516300310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pnmrs.2016.10.001" target="_blank" >10.1016/j.pnmrs.2016.10.001</a>
Alternative languages
Result language
angličtina
Original language name
NMR solution structure determination of large RNA-protein complexes
Original language description
Structure determination of RNA-protein complexes is essential for our understanding of the multiple layers of RNA-mediated posttranscriptional regulation of gene expression. Over the past 20 years, NMR spectroscopy became a key tool for structural studies of RNA-protein interactions. Here, we review the progress being made in NMR structure determination of large ribonucleoprotein assemblies. We discuss approaches for the design of RNA-protein complexes for NMR structural studies, established and emerging isotope and segmental labeling schemes suitable for large RNPs and how to gain distance restraints from NOEs, PREs and EPR and orientational information from RDCs and SAXS/SANS in such systems. the new combination of NMR measurements with MD simulations and its potential will also be discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
ISSN
0079-6565
e-ISSN
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Volume of the periodical
97
Issue of the periodical within the volume
November
Country of publishing house
GB - UNITED KINGDOM
Number of pages
25
Pages from-to
57-81
UT code for WoS article
000390507100003
EID of the result in the Scopus database
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