Test-Retest Reproducibility of Neurochemical Profiles with Short-Echo, Single-Voxel MR Spectroscopy at 3T and 7T

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00092578" target="_blank" >RIV/00216224:14740/16:00092578 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/mrm.26022/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/mrm.26022/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mrm.26022" target="_blank" >10.1002/mrm.26022</a>

Result language
angličtina
Original language name
Test-Retest Reproducibility of Neurochemical Profiles with Short-Echo, Single-Voxel MR Spectroscopy at 3T and 7T
Original language description
Purpose: To determine the test-retest reproducibility of neurochemical concentrations obtained with a highly optimized, short-echo, single-voxel proton MR spectroscopy (MRS) pulse sequence at 3T and 7T using state-of-the-art hardware. Methods: A semi-LASER sequence (echo time = 26-28 ms) was used to acquire spectra from the posterior cingulate and cerebellum at 3T and 7T from six healthy volunteers who were scanned four times weekly on both scanners. Spectra were quantified with LCModel. Results: More neurochemicals were quantified with mean Cramer-Rao lower bounds (CRLBs) <= 20% at 7T than at 3T despite comparable frequency-domain signal-to-noise ratio. Whereas CRLBs were lower at 7T (P<0.05), between-session coefficients of variance (CVs) were comparable at the two fields with 64 transients. Five metabolites were quantified with between-session CVs <= 5% at both fields.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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