Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00093866" target="_blank" >RIV/00216224:14740/16:00093866 - isvavai.cz</a>
Result on the web
<a href="http://www.nature.com/articles/ncomms13228" target="_blank" >http://www.nature.com/articles/ncomms13228</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ncomms13228" target="_blank" >10.1038/ncomms13228</a>

Result language
angličtina
Original language name
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF
Original language description
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF, a member of the poxvirus immune evasion superfamily, to antagonize GM-CSF (granulocyte macrophage colony-stimulating factor) and IL-2 (interleukin-2), two pleiotropic cytokines of the mammalian immune system. However, structural and mechanistic insights into the unprecedented functional duality of GIF have remained elusive. Here we reveal that GIF employs a dimeric binding platform that sequesters two copies of its target cytokines with high affinity and slow dissociation kinetics to yield distinct complexes featuring mutually exclusive interaction footprints.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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