Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00094376" target="_blank" >RIV/00216224:14740/17:00094376 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/17:00067538

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/bjh.14176/abstract;jsessionid=CCC32E2E63D96F860D239E95FFE3908B.f02t03</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bjh.14176" target="_blank" >10.1111/bjh.14176</a>

Result language

angličtina

Original language name

Single cell analysis revealed a coexistence of NOTCH1 and TP53 mutations within the same cancer cells in chronic lymphocytic leukaemia patients

Original language description

The clinical course in chronic lymphocytic leukaemia (CLL) patients is diverse, reflecting the heterogeneous biological background of this disease (Guieze &amp; Wu, 2015). Among reported defects, mutations in NOTCH1 and TP53 genes represent potent CLL progression drivers and contribute to disease chemo-refractoriness (Fabbri et al, 2011; Malcikova et al, 2015). Although parallel occurrence of NOTCH1 mutations and TP53 defects has been noted in CLL patients (Weissmann et al, 2013; Stilgenbauer et al, 2014), the clonal composition of these coexisting aberrations has not been yet studied. To clarify this phenomenon, we examined CLL patients with concurrently detected hotspot NOTCH1 and TP53 mutations using single cell analysis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30200 - Clinical medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British journal of haematology

ISSN

0007-1048

e-ISSN

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Volume of the periodical

178

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

979-982

UT code for WoS article

000411727800017

EID of the result in the Scopus database

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