Structure and dynamics of the RNAPII CTDsome with Rtt103
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00095104" target="_blank" >RIV/00216224:14740/17:00095104 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1712450114" target="_blank" >http://dx.doi.org/10.1073/pnas.1712450114</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1712450114" target="_blank" >10.1073/pnas.1712450114</a>
Alternative languages
Result language
angličtina
Original language name
Structure and dynamics of the RNAPII CTDsome with Rtt103
Original language description
RNA polymerase II (RNAPII) not only transcribes protein coding genes and many noncoding RNA, but also coordinates transcription and RNA processing. This coordination is mediated by a long C-terminal domain (CTD) of the largest RNAPII subunit, which serves as a binding platform for many RNA/protein-binding factors involved in transcription regulation. In this work, we used a hybrid approach to visualize the architecture of the full-length CTD in complex with the transcription termination factor Rtt103. Specifically, we first solved the structures of the isolated subcomplexes at high resolution and then arranged them into the overall envelopes determined at low resolution by small-angle X-ray scattering. The reconstructed overall architecture of the Rtt103–CTD complex reveals how Rtt103 decorates the CTD platform.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceeding of the National Academy of Sciences of the USA
ISSN
0027-8424
e-ISSN
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Volume of the periodical
114
Issue of the periodical within the volume
42
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
11133-11138
UT code for WoS article
000413237900048
EID of the result in the Scopus database
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