MEK inhibitors block growth of Ataxia Telangiectasia Mutated (ATM) mutant lung tumors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00100425" target="_blank" >RIV/00216224:14740/17:00100425 - isvavai.cz</a>
Result on the web
<a href="http://mct.aacrjournals.org/content/16/10_Supplement/PR14" target="_blank" >http://mct.aacrjournals.org/content/16/10_Supplement/PR14</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1158/1538-8514.SYNTHLETH-PR14" target="_blank" >10.1158/1538-8514.SYNTHLETH-PR14</a>

Result language
angličtina
Original language name
MEK inhibitors block growth of Ataxia Telangiectasia Mutated (ATM) mutant lung tumors
Original language description
Introduction: Lung cancer is the leading cause of cancer death worldwide. In the past decade, deep sequencing projects have shed light on the molecular drivers commonly found altered in NSCLC. As a result, the first molecularly targeted agents have been approved for the treatment of tumors presenting activating oncogenic events in EGFR or EML4/ALK. However, the translation into therapies for tumors presenting loss-of-function mutations has proven challenging and constitutes an unexplored and promising field. In order to narrow the gap between cancer genomics and effective treatments for tumors harboring mutations in well-defined tumor suppressor genes (such as PTEN, BRG1 or ATM), we have developed a genetically tractable lung cancer cell model. Focusing on lung adenocarcinoma, we have engineered a panel of isogenic cell lines capturing the molecular heterogeneity found in patients. This panel has been screened against a collection of drugs, comprising classical chemotherapeutics and kinase inhibitors, providing a comprehensive evaluation for hundreds of gene-drug interactions.
Czech name
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Czech description
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Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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