White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00102928" target="_blank" >RIV/00216224:14740/18:00102928 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/brb3.1039" target="_blank" >http://dx.doi.org/10.1002/brb3.1039</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/brb3.1039" target="_blank" >10.1002/brb3.1039</a>

Result language

angličtina

Original language name

White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study

Original language description

ABSTRACT Background: An evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET. Objectives: To investigate ET-related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry. Methods: Tract-based statistics approach (TBSS) was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age- and gender-matched healthy individuals. Clinical scales and tremor frequency and amplitude as measured by accelerometry were correlated with DTI data. Results: ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in non-motor regions including the inferior fronto-occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores. Conclusions: The results show that ET-related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain and Behavior

ISSN

2162-3279

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000449070600014

EID of the result in the Scopus database

2-s2.0-85050930566