Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106642" target="_blank" >RIV/00216224:14740/18:00106642 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1809642115" target="_blank" >http://dx.doi.org/10.1073/pnas.1809642115</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1809642115" target="_blank" >10.1073/pnas.1809642115</a>
Alternative languages
Result language
angličtina
Original language name
Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins
Original language description
T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data. We applied this framework to data from three pairs of identical twins immunized with the yellow fever vaccine. We identified 600 to 1,700 responding TCRs in each donor and validated them using three independent assays. While the responding TCRs were mostly private, albeit with higher overlap between twins, they could be well-predicted using a classifier based on sequence similarity. Our method can also be applied to samples obtained postinfection, making it suitable for systematic discovery of new infection-specific TCRs in the clinic.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
12704-12709
UT code for WoS article
000452866000064
EID of the result in the Scopus database
2-s2.0-85058309769