TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106643" target="_blank" >RIV/00216224:14740/18:00106643 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2018.187583" target="_blank" >http://dx.doi.org/10.3324/haematol.2018.187583</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2018.187583" target="_blank" >10.3324/haematol.2018.187583</a>

Result language

angličtina

Original language name

TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics

Original language description

Chronic lymphocytic leukemia is associated with a highly heterogeneous disease course in terms of clinical outcomes and responses to chemoimmunotherapy. This heterogeneity is partly due to genetic aberrations identified in chronic lymphocytic leukemia cells such as mutations of TP53 and/or deletions in chromosome 17p [del(17p)], resulting in loss of one TP53 allele. These aberrations are associated with markedly decreased survival and predict impaired response to chemoimmunotherapy thus being among the strongest predictive markers guiding treatment decisions in chronic lymphocytic leukemia. Clinical trials demonstrate the importance of accurately testing for TP53 aberrations [both del(17p) and TP53mutations] before each line of treatment to allow for appropriate treatment decisions that can optimize patients' outcomes. The current report reviews the diagnostic methods to detect TP53 disruption better, the role of TP53 aberrations in treatment decisions and current therapies available for patients with chronic lymphocytic leukemia carrying these abnormalities. The standardization in sequencing technologies for accurate identification of TP53 mutations and the importance of continued evaluation of TP53 aberrations throughout initial and subsequent lines of therapy remain unmet clinical needs as new therapeutic alternatives become available.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

haematologica

ISSN

0390-6078

e-ISSN

—

Volume of the periodical

103

Issue of the periodical within the volume

12

Country of publishing house

IT - ITALY

Number of pages

13

Pages from-to

1956-1968

UT code for WoS article

000451736600020

EID of the result in the Scopus database

2-s2.0-85060851454